Pocket Medicine (4)

This entry was posted by on Monday, 3 May, 2010 at

Comments of the week:

Maccabe466314@att.net
173.234.11.254

Youre so right. Im there with you. Your weblog is certainly worth a read if anyone comes throughout it. Im lucky I did because now Ive received a whole new view of this. I didnt realise that this issue was so important and so universal. You surely put it in perspective for me.

Per Karlqvist

December 25, 2010 at 1:55 pm

Quite insightful submit. Never believed that it was this simple after all. I had spent a good deal of my time looking for someone to explain this subject clearly and you’re the only one that ever did that. Kudos to you! Keep it up

========================================================

Adrenal glands and…Linus Pauling

This post has two distinct parts – one practical through which I help you immediately establish your adrenal glands state (a very important aspect because it concerns the functionality of the endocrine system and consequently your entire life strategy: from nutrition to state of mind (moods), and from memory to sexual potency); in the 2nd part is presented a critical evaluation of a very debated problem in nutrition and physiology, namely the metabolic meaning of over- / megadosing with ascorbic acid / Vitamin C – a  not so appropriate idea due to Linus Pauling, Nobel prize for Chemistry.


The shape of your adrenals

This problem, as previously stated, is fundamental and the most accurate solution to it would be the urine collection during a 24-hour period followed by the analysis of adrenal hormones, especially cortisol; if you are interested by an accurate determination the first step would be to select a highly specialized laboratory. In the following I will suggest some alternative methods, a little less accurate, but nonetheless indicative enough to determine the shape of your adrenals during the test. I will mention that the vast majority of the Western people (4/5 at least ! ) have underactive adrenals, therefore your chance to be included in this group (strongly and prolonged  stressed) is about 80%. For a more elaborated exposition of this problem ,  I strongly recommend the Dr. L. Wilson’s book ” Adrenal Fatigue – the 21 Century Stress Syndrome “.

  • The Sargent test:

Take a fork and gently to moderately stroke it against the interior of your forearm skin (about 10 cm length). If after 10-15 seconds the line(s) redden(s) there is a chance that your adrenals are in good shape (the red color being due to the normal  defensive, inflammatory mechanism). If the redness takes place later (about 60 seconds) your adrenals are probably underactive. An extreme exhaustion stage of adrenals is indicated by total perspiration inability.

  • Excessive craving for salt (salty foods)

as well as sweets ( fruits, juices, cookies ) and even the irrepressible inclination toward coffee and / or tobacco point too to adrenal weakness, the organism trying to repair the general lack of energy through stimulation, as well as the dehydration state through a forced, non-metabolic hydration; it is well known that the sodium and water loss is correlative with the cortisol and aldosterone deficiency. Anyway, if you try to ameliorate your dehydration by consuming salty foods do not forget to support your adrenals by ingesting choline bitartrate (250 mg x 2 per day).

  • Skin dehydration

By pinching your skin (best done on the back of your hand ) , if the skin fold persists several seconds (the skin not immediately returning to the initial condition) it can also be concluded that your adrenals are underactive and consequently your cortisol / aldosterone / sodium / hydration are all deficient.

What can be done? If you are interested to effectively improve your adrenal activity the first recommended step is to understand the mechanisms that led to this underactive state. A more detailed presentation of this problem can be found on this blog under the title “ Copper Overload – the Western Metabolic Bomb ”, especially useful to all people with underactive adrenals who are unable to normalize their intracellular copper excess, being exposed to ample metabolic risks, usually designated as stress syndrome and metabolic syndrome ( insulin resistance , IR ), due to some  complex , resonant mechanisms represented in a simplified form using the following scheme :

Cu ↑ → vit. C↓, choline ↓ ( stress and  adrenal deactivation )

Cu↑  → Ca↑  ( stress and obesity)

Cu↑  →  Cr↓ ( stress and metabolic syndrome = IR  )

Cu↑→ Mn↓, Zn↓,Se↓..( stress and hypothyroidism): T4 —⁄— T3

    Adrenal Deactivation

    It is a relatively slow process (which can also happen suddenly under the influence of some very intense emotional impulses such as the abrupt loss of someone close to you, a unforeseen bankruptcy, etc.), cumulative and still reversible. Biochemists have established a firm direct connection between stress, the shape of the adrenals and the intracellular copper excess: any kind of stress (physical, psychical, nutritional: coffee,..)  is always followed by excessive copper accumulation; here we are dealing with a vicious circle or a positive feedback: weak adrenals lead to higher intracellular copper and high intracellular copper leads to even lower adrenal activity. The toxicity of the intracellular copper stores is manifested through profound dysregulation of the mineral and general metabolism – this complex ( much beyond the standard oxidative toxicity ) effect was designated by me through the term “ interference toxicity ”, the scheme below  suggesting this real complexity just for the case of the  metabolic syndrome .

    The most direct negative influence triggered by the  copper excess (through de-retention of its antagonist: Zn, Mn, Se,…)  is exerted on the thyroid gland of which activity is drastically reduced (hypothyroidism). The typical bio-chemical sequence of this very common degenerative process is the following:

    Stress ↑  →  Cortisol ↑  →  MT (stress protein) ↑  →  Cu ↑  →   Hypothyroidism

    An alternative degenerative process, due to copper excess, is the correlative intracellular calcium buildup ( Cu↑  → Ca ↑), with a direct diminishing impact upon the metabolic rate resulting in additional fat accumulations (obesity). In this context you can commonly encounter the inexact phrase “copper is the greatest depressor of the metabolic rate / activity”, correctly being to incriminate not the copper itself (which is a vital mineral!) but only the copper excess (Cu↑) which is a totally different matter. Based on this model centered on the so-called copper bio-unavailability (explained for the first time in the section “Copper Overload – …” already mentioned) can suggest a shortest / direct pathway to adrenal activation: bio-mobilization of copper excess that can be accomplished in multiple ways, one of them (that I do not recommend it because it replaces one type of degeneration with another) consists in speculating the antagonistic relationship between Cu and vitamin C: through over- or megadosing of vitamin C the toxic copper deposit (calcium store also) is/ are really diminished, activating at the same time the adrenal glands (all these coming with a high metabolic price).  Therefore it is recommended to employ some synergistic procedures using concomitantly and in optimal doses (established by me after 2002) not just one but several members of copper antagonist family.

    Linus Pauling and adrenal glands: biology is not quite…chemistry

    The deficiencies of…Linus Pauling

    One of the defining features of modern medicine – one that we are still facing – is the undervaluation of the mineral system in normal and pathological physiology, especially the ignoring / undervaluing of the mineral individual status. Linus Pauling – one of the greatest chemists of all time – has brought to attention the mineral role in health or sickness releasing the following famous adagio: “ Every disease could be ultimately traced back to a mineral deficiency.” I consider this statement as being inexact and in section “Copper Overload – ..” I clearly show that the mineral excess should be blamed, the excess copper being the one determining (especially through de-retention) the deficiencies of all its antagonists: zinc, selenium, chromium, etc. In an improved version Pauling’s statement would be: Every disease could be ultimately traced back to a mineral imbalance.

    Another correction that has to be kept in mind concerns the fact that terms such as deficient, normal or excess do not correspond to a homogenous situation, easy to be generalized, but represent just as many individual determinations: what is perfectly normal for some could constitute deficiency or excess for others. Both just mentioned corrections make the theoretical and applicative value of Pauling’s adagio to be drastically diminished.

    The excesses of Linus Pauling

    Is vitamin C megadosing (procedure mainly promoted by L. Pauling) seeking a daily ingestion for everyone of 5 g – 20 g ascorbic acid a valid physiological procedure? (for the moment we are overlooking the fact that ascorbic acid is only the antioxidant part of the genuine vitamin C ).  Is overdosing with ascorbic acid an efficient therapeutic solution for the common cold or flu? To both questions, my answer, based on several decades of bio-chemical experience, is a negative one. The fact that the Western society is strongly stressed (and the stress of any nature equals excess cortisol / intracellular copper) has being the premise – methodologically fragile – of this megadosing procedure, because vitamin C as copper (and calcium ) antagonist really contributes to the diminishing of the toxic deposits of both minerals and correlatively to the activation of weakened adrenals, with certain beneficial ( and detrimental too ! ) effects upon health / well-being. But a word of caution: similar effects (equally positive or negative) may be obtained with any other copper antagonists, for example chromium and sulfur ( this fact omitted by Pauling and his followers has been verified by me at the Transilvania University – Brasov and later in Evanston – IL). Therefore are we going to need a new Pauling for every other copper antagonist ? To mention that overdosing with ascorbic acid is profoundly detrimental to patients with initial copper deficiency (leading to inflammation, infection) whilst for the patients with normal copper levels it is flatly not necessary. As previously shown, utilizing over / megadoses of ascorbic acid is unbalancing because even before normalizing the weak adrenals, the seric calcium is critically reduced, activating this way the PTH (para-thyroid hormone) with ample metabolic complications. Other important unbalances – found at some athletes who decided on trying not mega but just overdosing with ascorbic acid – are suggested by the following schema:

    Ascorbic acid ↑ → Ca ↓, Zn ↓, Mn ↓

    ( for those not used to read such schemas I underline that these are symptoms of sciatica, low energy and sexual insufficiency to some youngsters between 20-30 years ).

    In conclusion:

    If the overdose procedure would have been limited to the important – however modest – status of partial, temporary correction of copper excess through vitamin C supplementation everything would have been somewhat normal but then the procedure – and its promoters – would have reserved a subsidiary position analog to “take statins because you have high cholesterol.” Unfortunately we are dealing with an over solicitation of this procedure (as a distinct form of ortho medicine and nutrition) which unnecessarily raises principial problems since it involves:

    • Ignoring / undervaluing of metabolic complications;
    • Counterproductive application to certain social groups (see above)
    • Overlooking (special, analytical) the excess of antagonist minerals (copper, calcium) accompanied by the real risk of causing permanent deficiencies of the two vital minerals

    Vitamin C (ascorbic acid even more because it is actually a drug) has to be utilized in OPTIMAL amounts – not higher or lower – rigorously related to biochemical individuality. Violating of optimal condition (both positive or negative imbalances) is / are  punished by the organism in a rational, intelligible manner: the vitamin C excess leads to inflammations / infections due to functional copper deficiency established in the system (caution: a first sign of this state is the inflammation of the right eye), while vitamin C deficiency leads to degeneration due to the uncontrolled increase of toxic store of intracellular copper.

    Worth mentioning: the efficient maintaining of quality of life / living is attained not as much through overdosing of copper antagonists (vitamin C, sulfur, chromium, etc.) but rather through identifying and decisive elimination of excessive stress sources from personal life.

    43 Responses to “Pocket Medicine (4)”

    1. Hey – nice blog, just looking around some blogs, appears a pretty great platform you might be using. I’m presently making use of WordPress for a few of my sites but looking to alter 1 of them about to a platform similar to yours like a trial run. Something in particular you would recommend about it?

    2. Youre so right. Im there with you. Your weblog is definitely worth a read if anybody comes across it. Im lucky I did because now Ive obtained a whole new view of this. I didnt realise that this issue was so important and so universal. You definitely put it in perspective for me.

    3. Dude, please tell me that youre heading to publish far more. I notice you havent written another weblog for a while (Im just catching up myself). Your blog is just as well important to be missed. Youve got so considerably to say, these knowledge about this subject it would be a shame to see this blog disappear. The internet needs you, man!

    4. Thank you for another wonderful post. Exactly where else could anyone get that type of facts in such a perfect way of writing? I’ve a presentation subsequent week, and I’m on the appear for these data.

    5. Hey – nice site, just looking around some websites, seems a pretty great platform you are using. I’m currently using Drupal for a few of my sites but looking to change one of them over to a platform very similar to yours as a trial run. Anything in particular you would suggest about it?

    6. I thought it was heading to become some boring previous publish, but it definitely compensated for my time. I’ll publish a link to this web page on my weblog. I am positive my guests will find that incredibly useful.

    7. Please tell me that youre going to keep this up! Its so great and so important. I cant wait to read much more from you. I just feel like you know so significantly and know how to make people listen to what you might have to say. This weblog is just too cool to be missed. Terrific things, really. Please, PLEASE keep it up!

    8. Dude, please tell me that youre heading to publish much more. I notice you havent written another weblog for a while (Im just catching up myself). Your weblog is just too important to be missed. Youve acquired so very much to say, such knowledge about this topic it would be a shame to see this blog disappear. The internet needs you, man!

    9. I like when you talk about this type of stuff in your posts. Perhaps could you continue to do this?

    10. CNA Training
      There is evidently a bundle to realize about this. I consider you made some good points in features also.

    11. First of all, allow my family enjoy a person’s command during this matter. Even though this is certainly brand new , nevertheless soon after registering your site, this intellect has exploded extensively. Allow all of us to take hold of one’s rss to help keep in touch with at all probable messages Sincere understand but will pass it on to help admirers and my private are living members

    12. Please tell me that youre going to keep this up! Its so good and so important. I cant wait to read additional from you. I just really feel like you know so substantially and know how to make people listen to what you’ve got to say. This weblog is just as well cool to become missed. Wonderful things, definitely. Please, PLEASE keep it up!

    13. I believed it was going to be some boring old publish, but it truly compensated for my time. I’ll post a hyperlink to this web page on my blog. I’m sure my website visitors will locate that really helpful.

    14. Please tell me that youre heading to keep this up! Its so very good and so important. I cant wait to read far more from you. I just feel like you know so considerably and know how to make people listen to what you have to say. This blog is just too cool to become missed. Fantastic stuff, actually. Please, PLEASE keep it up!

    15. nice post. thanks.

    16. Resources such as the 1 you mentioned here will be extremely helpful to myself! I will publish a hyperlink to this web page on my particular weblog. I am sure my site visitors will discover that quite useful.

    17. Ohh very much thanks admin

    18. Youre so right. Im there with you. Your weblog is certainly worth a read if anyone comes throughout it. Im lucky I did because now Ive received a whole new view of this. I didnt realise that this issue was so important and so universal. You surely put it in perspective for me.

    19. Quite insightful submit. Never believed that it was this simple after all. I had spent a good deal of my time looking for someone to explain this subject clearly and you’re the only one that ever did that. Kudos to you! Keep it up

    20. Thanks for taking the time to discuss this, I feel strongly about it and enjoy learning additional on this topic. If achievable, as you gain knowledge, would you mind updating your weblog with more info? It’s extremely helpful for me.

    21. Sick! Just received a brand-new Pearl and I can now read your weblog on my phone’s browser, it didn’t function on my aged 1.

    22. Took me time to read all the comments, but I truly enjoyed the write-up. It proved to become Incredibly useful to me and I am sure to all the commenters here It’s always good when you can not only be informed, but also entertained I’m certain you had fun writing this article.

    23. Resources these as the one you mentioned here will be extremely helpful to myself! I’ll publish a hyperlink to this web page on my personalized weblog. I am positive my site site visitors will locate that fairly effective.

    24. yesss very thanks man i love this site

    25. I would wish to thank you for the efforts you might have made in writing this article. I am hoping the same greatest perform from you in the long term too. In fact your inventive writing skills has inspired me to begin my very own BlogEngine blog now.

    26. Please tell me that youre heading to keep this up! Its so very good and so important. I cant wait to read a lot more from you. I just feel like you know so a lot and know how to make people listen to what you’ve to say. This weblog is just too cool to be missed. Terrific things, truly. Please, PLEASE keep it up!

    27. Congratulations on having 1 of the most sophisticated blogs Ive arrive across in some time! Its just incredible how much you can take away from a little something simply because of how visually beautiful it is. Youve put with each other a wonderful blog space –great graphics, videos, layout. This is unquestionably a must-see blog!

    28. Thank you for another terrific article. Where else could anyone get that kind of data in this kind of a ideal way of writing? I have a presentation next week, and I am on the appear for this kind of details.

    29. Nice to be visiting your weblog again, it has been months for me. Nicely this article that i’ve been waited for so lengthy. I will need this post to complete my assignment inside the university, and it has exact same topic with your post. Thanks, excellent share.

    30. I’m happy I found this weblog, I couldnt uncover any information on this subject matter prior to. I also run a site and if you want to ever serious in a little bit of guest writing for me if achievable really feel free to let me know, i’m always appear for people to check out my site. Please stop by and leave a comment sometime!

    31. I don’t always agree with your posts, but this was dead on, way to go!

    32. Good is good, but better carries it.

      ———————————–

    33. great thanks \o/

    34. Great information! I’ve been looking for something like this for a while now. Thanks!

    35. Greatings, Nombre de new-holism.com a GoogleReader!

      Dolly

    36. Nice fill someone in on and this mail helped me alot in my college assignement. Gratefulness you on your information.

    37. Amiable brief and this fill someone in on helped me alot in my college assignement. Thanks you on your information.

    38. Great site. A lot of useful information here. I’m sending it to some friends!

    39. My cousin recommended this blog and she was totally right keep up the fantastic work!

    40. It’s posts like this that keep me coming back and checking this site regularly, thanks for the info!

    41. Valuable info. Lucky me I found your site by accident, I bookmarked it.

    42. Great, I never knew this, thanks.

    Trackbacks/Pingbacks

    1. New-holism